Fig. 2: Phenotypic correlations between any site OA and each of specific types of severe cardiovascular disease. | Nature Communications

Fig. 2: Phenotypic correlations between any site OA and each of specific types of severe cardiovascular disease.

From: Shared genetic factors between osteoarthritis and cardiovascular disease may underlie common etiology

Fig. 2

Phenotypic correlations (black bars, i.e. correlations between osteoarthritis and specific, severe cardiovascular disease (CVD) in one individual) with 95% confidence interval, and parts of this correlation that are explained by additive genetic factors, common- and unique environmental factors. Analyses are performed for any site OA (hip, knee and/or hand OA) combined with specific CVDs on 29 985 twin pairs, i.e. where 39 had cardiac arrythmias and any site OA, 49 had CHD and any site OA, 15 had heart failure and any site OA, and 18 had stroke and any site OA (pair level). Please note that the total correlation (denoted with black bars) can be lower than the sum of A and C components, when the E component has negative value. CHD: coronary heart disease. Data are presented as correlations +/− 95% confidence intervals. Source data are provided as a Source Data file.

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