Fig. 2: The brain-wide BOLD functional maps of awake wild-type (WT) and Alzheimer’s disease (AD) mice with visual stimulation. | Nature Communications

Fig. 2: The brain-wide BOLD functional maps of awake wild-type (WT) and Alzheimer’s disease (AD) mice with visual stimulation.

From: Identifying the bioimaging features of Alzheimer’s disease based on pupillary light response-driven brain-wide fMRI in awake mice

Fig. 2

The functional maps of awake mice show significant BOLD activation in the visual cortex (VC), superior colliculus (SC), retrosplenial cortex (RSP), lateral geniculate nucleus (LGN), and anterior cingulate area (ACA) from both WT (upper panel) (n = 13 mice with 58 trials) and AD (lower panel) mice (n = 9 mice with 60 trials; two-sided t-test p < 0.001, FDR < 0.01, minimum cluster size = 200 voxels). Source data are provided as a Source Data file.

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