Fig. 3: Transcriptional programs induced by catalase activity deficiency sensitize Mtb to bedaquiline. | Nature Communications

Fig. 3: Transcriptional programs induced by catalase activity deficiency sensitize Mtb to bedaquiline.

From: Catalase activity deficiency sensitizes multidrug-resistant Mycobacterium tuberculosis to the ATP synthase inhibitor bedaquiline

Fig. 3

a Expression of the transcriptional regulators Rv3160c (p = 0.0042), kmtR (p = 0.0022), and prpR (p ≤ 0.0001) is higher in untreated ∆katG cells than in H37Rv cells as measured by RNA sequencing. Expression data reported as smooth quantile normalized log2 sequencing counts. Two-sided Welch’s t-tests were performed on RNA expression data with comparisons between untreated wild-type and ∆katG cells. b Rv3160c over-expression sensitizes cells to BDQ-inhibited ATP synthesis and growth in 7-day dose-response experiments as determined by BacTiter-Glo and optical density. c kmtR over-expression sensitizes cells to BDQ-inhibited ATP synthesis in 7-day dose-response experiments. n = 3 biological replicates for each experiment. **p ≤ 0.01. ****p ≤ 0.0001. Data depicted as mean ± SEM. Source data are provided in the Source Data file.

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