Fig. 7: KLHDCX family C-terminal anchors mediating C-degron placement and recognition. | Nature Communications

Fig. 7: KLHDCX family C-terminal anchors mediating C-degron placement and recognition.

From: Structural basis for C-degron selectivity across KLHDCX family E3 ubiquitin ligases

Fig. 7: KLHDCX family C-terminal anchors mediating C-degron placement and recognition.The alternative text for this image may have been generated using AI.

a Cartoon representation of the arrangement of blades 1–6 from the β-propeller domain of KLHDC2. The relative positioning of the degron C-terminal carboxylate (orange, surface, colored by element) and its RSR recognition motif are shown. b Same as (a), but for KLHDC3s RSR motif. c Same as (a), but for KLHDC10s FSR motif. d Cartoon representation of the structure of KLHDC2 (rainbow, 8EBL.pdb) with the degron C-terminal carboxylate (orange, spheres, colored by element) and its RSR (pale green, surface, colored by element) recognition motif are shown. e Same as (d), but for KLHDC3 RSR motif (pale yellow, surface, colored by element). f Same as (d), but for KLHDC10 FSR motif RSR (red, surface, colored by element).

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