Fig. 2: Cellular landscape of the developing spinal cord. | Nature Communications

Fig. 2: Cellular landscape of the developing spinal cord.

From: HOX gene expression in the developing human spine

Fig. 2: Cellular landscape of the developing spinal cord.The alternative text for this image may have been generated using AI.

A Uniform manifold approximation and projection of progenitors and neurons in the nascent cord. B Dotplot of mean expression values of marker genes amongst cells of the fetal cord. Dot size corresponds to the percentage of cells with non-zero expression. Pct. Exp, percentage of expressing cells; Av. Exp, average expression in cell type. C Left panel: Spatial heatmap showing cellular abundancy scores in the Post-conception week 7 spinal cord calculated using cell2location on spatial transcriptomics data. Right panel: inferred location of single cells in the PCW7 spinal cord using k-nearest neighbour prediction on in-situ sequencing data. ISS, in-situ sequencing. D Left panel: Spatial heatmaps of spatial transcriptomics data showing expression of marker genes for different neuroprogenitor populations from A & B; Right panel: gene expression of neuroprogenitor marker genes from in-situ sequencing data. E Left panel: Spatial heatmaps of spatial transcriptomics data showing expression of marker genes for different neuronal populations from A & B; Right panel: gene expression of neuronal marker genes from in-situ sequencing data. Source data are provided as a Source Data file.

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