Fig. 5: HOX gene expression in neural crest-derived cells. | Nature Communications

Fig. 5: HOX gene expression in neural crest-derived cells.

From: HOX gene expression in the developing human spine

Fig. 5: HOX gene expression in neural crest-derived cells.The alternative text for this image may have been generated using AI.

A Dotplots quantifying log-normalised HOX gene expression across spinal segments in stationary, haematopoietic and neural crest cell types. Dot size corresponds to the fraction of cells with non-zero expression. Coloured boxes highlight genes represented in B. C, cervical; T, thoracic; L, lumbar; S, sacral; Pct. Exp, percentage of expressing cells; Av. Exp, average expression in cell type. B Top panel: Spatial heatmaps of HOX gene expression in neural crest cell types at PCW9 from spatial transcriptomics data. Dot colour represents genes coloured in A. Bottom panel: Expression of HOX gene modules from in-situ sequencing across spinal segments. Dot colour corresponds to expression of the gene module highlighted in the legend (orange- cervical; blue- thoracic; green- lumbar). PCW = Post-conception week. ISS = in-situ sequencing. C Schematic illustrating workflow for analysis of in-situ sequencing data at single cell resolution. ISS, in situ-sequencing. D Dotplots quantifying log-normalised expression levels in B.Left panel: spatial transcriptomics data. Right panel: in-situ sequencing data. Dot size corresponds to the fraction of voxels/cells with non-zero expression. C, cervical; T, thoracic; L, lumbar. Source data are provided as a Source Data file.

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