Fig. 6: Immune response and pro-tumor response of STING@nanomotor.

The representative flow cytometry plots of (a) CD4⁺ and CD8⁺ T cells, and (b) regulatory T cells. c The corresponding percentage of CD4⁺, CD8⁺ T cells (n = 4 mice per group) and regulatory T cells in whole bladder cells. Data are presented as mean values and error bars represent the S.D. and statistical analysis was performed via two-sided t-test (n = 3 mice per group). d The flow cytometry comparison of CD80, CD86, and MHC-II expression on dendritic cells from each bladder tumor and (e) the corresponding mean fluorescent intensity of expressed CD80, CD86, and MHC-II. CD8⁺ T cells were identified as DAPI⁻/CD45⁺/CD3ε⁺/CD4⁻/CD8a⁺ cells, CD4⁺ T cells as DAPI⁻/CD45⁺/CD3ε⁺/CD8a⁻/CD4⁺ cells, T_reg cells as FVS450⁻/CD45⁺/CD4⁺/CD25⁺ cells and dendritic cells as DAPI⁻/CD45⁺/CD11c⁺ cells. Data are presented as mean values and error bars represent the S.D., and statistical analysis was performed via two-sided t-test (n = 3 mice per group). Source data are provided as a Source Data file.