Fig. 3: Scope of this reaction. | Nature Communications

Fig. 3: Scope of this reaction.

From: Enantioselective synthesis of inherently chiral sulfur-containing calix[4]arenes via chiral sulfide catalyzed desymmetrizing aromatic sulfenylation

Fig. 3: Scope of this reaction.

aThe reaction was conducted with 2 (0.1 mmol), 3 (0.12 mmol), (S, R)-1g (0.01 mmol), pTSA (0.01 mmol), HFIP (0.2 mmol), and 3 Å MS (40 mg) in DCM (2.0 mL) at −10 °C under Ar. Isolated yields are shown. The ee values were determined by HPLC or Supercritical Fluid Chromatography (SFC). bThe reaction was performed at −20 °C. cThe reaction was performed at 0 °C. dThe reaction was performed at 10 °C. e(R, S)-1g (0.015 mmol) was used instead of (S, R)−1g. pTSA = p-toluenesulfonic acid, HFIP = hexafluoroisopropanol.

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