Fig. 1: Global genomic alterations in 204 Chinese primary ICCs. | Nature Communications

Fig. 1: Global genomic alterations in 204 Chinese primary ICCs.

From: Whole-exome sequencing reveals genomic landscape of intrahepatic cholangiocarcinoma and identifies SAV1 as a potential driver

Fig. 1

A Mutational burden in coding regions across 204 ICCs (top panel). Distribution of six substitution patterns sorted by the number of somatic coding mutations (middle panel). Somatic copy number alterations, including copy number gains and losses in each patient (bottom panel). B Patterns of six mutation signatures (Signatures A, B, C, D, E, and F) identified in 204 ICCs; the most similar COSMIC signature to each is also indicated. C Unsupervised hierarchical clustering of 204 primary ICCs based on the intensity of the signatures in each sample. SNV single-nucleotide variants, Indel insertions or deletions. Source data are provided as a Source Data file.

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