Fig. 2: Significantly mutated protein-coding genes and associations with patient outcome. | Nature Communications

Fig. 2: Significantly mutated protein-coding genes and associations with patient outcome.

From: Whole-exome sequencing reveals genomic landscape of intrahepatic cholangiocarcinoma and identifies SAV1 as a potential driver

Fig. 2

A Thirteen genes with statistically significant levels of mutation (MutSigCV, FDR < 0.1), together with EPHA2, CDKN1B, and ATM with FDR < 0.2, and significant copy number alterations in likely cancer driver genes are shown. B Comparison of mutation frequencies for 13 significantly mutated genes between the 204 ICCs in our cohort and ICCs from other cohorts, Chi-square test. C Proportions of 204 ICCs carrying TP53, KRAS, ELF3, and SAV1 mutations. D Tumor recurrence rates in patients with HCC carrying different numbers of mutated genes (TP53, KRAS, ELF3, and SAV1). E Kaplan–Meier survival analysis showing overall survival and recurrence-free survival based on TP53, KRAS, ELF3, and SAV1 mutations. P: log-rank test, two-sided. TNM tumor node metastasis, LN lymph node, TMB tumor mutational burden. Source data are provided as a Source Data file.

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