Fig. 4: Clinical significance of SAV1 mutation in 672 ICCs. | Nature Communications

Fig. 4: Clinical significance of SAV1 mutation in 672 ICCs.

From: Whole-exome sequencing reveals genomic landscape of intrahepatic cholangiocarcinoma and identifies SAV1 as a potential driver

Fig. 4: Clinical significance of SAV1 mutation in 672 ICCs.The alternative text for this image may have been generated using AI.

A Schematic diagram of the location of the mutation sites in SAV1 identified in this study. B Representative SAV1 staining in peritumor tissues and tumor tissues with wild-type SAV1 or mutant SAV1 (R47X). The statistics of SAV1 staining density in different groups are shown. Scale bars = 100 μm. In the boxplots, the central line represents median, the bounds of boxes represent the first and third quartiles, and the upper and lower whiskers extend to the highest or the smallest value. Student’s t-test, two-sided. C Kaplan–Meier survival analysis showing overall survival and recurrence-free survival based on SAV1 mutation and expression level. P: log-rank test, two-sided. WT wild-type, MT mutation-type. Source data are provided as a Source Data file.

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