Fig. 3: Deletion of HMGA1 inhibits the occurrence and development of CRC. | Nature Communications

Fig. 3: Deletion of HMGA1 inhibits the occurrence and development of CRC.

From: High mobility group A1 (HMGA1) promotes the tumorigenesis of colorectal cancer by increasing lipid synthesis

Fig. 3

a Schematic diagram of AOM/DSS induction in Hmga1flox/flox and Hmga1△IEC mice. b Representative macroscopic views of colorectum from control and CRC mice. The colorectal length of mouse was measured. c Representative images of CRC. d The number and size of tumors in the entire colorectum per mouse were measured. e Survival curve of the Hmga1flox/flox (control) and Hmga1△IEC mice with the induction of CRC. f HE staining of colorectum from control and AOM/DSS-induced Hmga1flox/flox and Hmga1△IEC mice (Scale bar = 20 μm. Representative images from 3 independent experiments). Percentages of LGD, HGD, and carcinoma in the tissues were determined. g Representative images of IHC staining for HMGA1 and Ki67 in normal colorectum and CRC (Scale bar = 20 μm). Data are presented as mean ± SD. Statistical significance was determined by two-tailed unpaired t-test (b, d, g) or log-rank test (e). n = 12. LGD: low-grade dysplasia; HGD: high-grade dysplasia. Source data are provided as a Source Data file.

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