Table 3 Linear regression analysis of predictors of TLG at week 8; N = 24

From: PET-CT outcomes from a randomised controlled trial of rosuvastatin as an adjunct to standard tuberculosis treatment

Predictor variables

Reference TLG Univariable analysis

Univariable Parameter estimate (95% CI)

P

Reference TLG multivariable analysis

Multivariable Parameter estimate (95% CI)

P

Age

477.3

−3.3 (−17.6, 11.0)

0.64

 

-

 

Female sex

247.0

     

Male sex

 

+145.7 (−313.4, 604.7)

0.52

 

-

 

Philippines

435.2

     

Vietnam

 

−140.1 (−512.8, 232.6)

0.44

 

-

 

Smoker

  

0.54

 

-

 

Current

622.6

-

    

Ex-smoker

 

−329.7 (−942.4, 283.1)

    

Never

 

−273.4 (−866.8, 319.9)

    

Standard treatment

476.6

     

Rosuvastatin treatment

 

−228.7 (−591.4, 134.0)

0.20

 

-

 

No of cavities, week 8

174.2

+ 33.7 (7.6, 59.8)

0.01

 

-

 

Cavity volume, week 8

302.2

+ 13.1 (−9.9, 36.2)

0.25

 

-

 

CT Cavity diameter, week 8

193.8

+ 3.74 (0.34, 7.1)

0.03

 

-

 

Negative culture at week 8

305.2

  

−81.3

  

Positive culture at week 8

 

+ 342.4 (−139.5, 824.4)

0.16

 

+ 438.5 (111.1, 765.9)

0.012

Xpert semiquantitative value

 

-

0.0002

  

0.0001

Low

64.8

     

Medium

 

+ 16.2 (−356.0, 388.4)

  

+ 162.4 (−173.1, 497.9)

 

High

 

+ 667.2 (284.4, 1050.0)

  

+ 703.7 (376.3, 1031.2)

 

Smear

Negative

117.8

-

0.52

 

-

 

Scanty

 

+ 119.3 (−295.3, 530.9)

    

1 + 

 

+ 284.2 (−275.2, 843.5)

    

2 + 

 

+ 354.1 (−230.1, 938.3)

    

3 + 

 

+ 478.7 (−141.0, 1098.3)

    
  1. The number of cavities, cavity volume and diameter were based on CT scan analysis. Percentage of lung affected on chest x-ray. Xpert semi-quantitative value and smear was the result available at trial entry. Source data are provided as a Source Data file.