Fig. 1: Endometriosis-associated mechanical allodynia is mediated by the complement system C5a.
From: Schwann cell C5aR1 co-opts inflammasome NLRP1 to sustain pain in a mouse model of endometriosis
a Time-dependent periorbital (PMA), hind paw (HMA) and abdominal (AMA) mechanical allodynia in endometriotic (endo) or Sham C57BL/6 J female (B6) mice. Proteome profiler array (b) and single analyte C5a assay (c) in plasma samples from endo and Sham B6 mice. d C5 assay in plasma samples from endo patients (n = 19) or healthy subjects (n = 15) (control). e Time-dependent C5a levels in plasma samples from endo and Sham B6 mice. f and g Timeline of the DF2593A (DF25) treatment schedule and time-dependent PMA, HMA, and AMA in endo B6 mice after intragastric (i.g.) administration of DF25 (1 mg/kg) or vehicle (Veh) and Sham mice. (n = 8 mice per group). Data are mean ± s.e.m. a, e, f, g 2-way ANOVA, Bonferroni correction; c, d 2- tailed Student’s t test. *P < 0.05, **P < 0.01, ***P < 0.001, ****P < 0.0001 vs. Sham ##P < 0.01, ####P < 0.0001 vs. Endo+Veh DF25. Source data are provided as a Source Data file.
