Fig. 5: Cidal antibiotics liberate more DNA from bacteria than static drugs.
From: Bactericidal antibiotic treatment induces damaging inflammation via TLR9 sensing of bacterial DNA
A Alexa 647-labeled cEC1 bacteria (red) were incubated with no antibiotics, static antibiotics or cidal antibiotics as indicated for 6 h before Hoechst staining for external DNA (cyan). One representative image is shown. B High-content imaging quantification of extracellular DNA from the samples from A-B. ***P < 0.001, by two-tailed t test, with three independent measurements per group displayed (A, B) are representative of two independent experiments. Error bars display SEM. Source data and exact p-values are provided as a Source Data file.
