Fig. 6: Mutation of Y173A in GrpEL1 results in a shift of the Hsmortalin SBD. | Nature Communications

Fig. 6: Mutation of Y173A in GrpEL1 results in a shift of the Hsmortalin SBD.

From: Structural insights into GrpEL1-mediated nucleotide and substrate release of human mitochondrial Hsp70

Fig. 6: Mutation of Y173A in GrpEL1 results in a shift of the Hsmortalin SBD.

A DeepEMhancer-sharpened map of mortalinR126W-GrpEL1Y173A. Shadow represents the silhouette of the mortalinR126W-GrpEL1WT SBD position. B Superposition of mortalinR126W-GrpEL1WT and mortalinR126W-GrpEL1Y173A. In the mortalinR126W-GrpEL1Y173A structure, the SBD is translated ~ 6 Å away from GrpEL1-B compared to WT. C DeepEMhancer-sharpened map of mortalinR126W-GrpEL1Y173A−lid. Shadow represents the silhouette of the mortalinR126W-GrpEL1WT SBD position.

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