Table 1 Overview of innate lymphocytes
From: Approaches to investigate tissue-resident innate lymphocytes metabolism at the single-cell level
Immune cell subsets | Nomenclature | Surface markers | Transcription factors | Development | Tissue locations | Cytokine and effector profile |
|---|---|---|---|---|---|---|
ILC | cNK, trNK | NK1.1, NKp46, CD49b | EOMES, T-bet | Bone marrow | Lymphoid and non-lymphoid tissues | IFNγ, TNFα, cytotoxic molecules |
ILC1 | NK1.1, NKp46, CD49a, CD200R1 | HOBIT, T-bet | Bone marrow | Non-lymphoid tissues | IFNγ, TNFα | |
ILC2 | ICOS, IL17Rβ | GATA-3, RORα | Bone marrow | Most abundant in the lung | IL-4, IL-5, IL-9, IL-13, AREG | |
ILC3 | NKp46, AhR | RORγt, T-bet, | Bone marrow | Most abundant in the gut | IL-17, IL-22, GM-CSF | |
LTi | CCR6 | RORγt | Bone marrow | Lymphoid tissues | IL-17, IL-22 | |
γδ T cells | γδ17, γδIFN | CD27, CD45RB, CD44 | RORγt, T-bet, | Thymus | Most abundant in the intestine, skin, brain, adipose tissue | IL-17, IFNγ |
iNKT cells | NKT1 | CD24lo, NK1.1hi, CD27hi, CXCR3+ | T-bet | Thymus | Most abundant in liver, spleen, adipose tissue | IFNγ, IL-2, IL-4, IL-10, IL-17, TNF |
NKT2 | CD24lo, CD27hi, CD4+ | GATA-3, PLZF | ||||
NKT17 | CD24lo, CCR6+, CD103hi, SDC-1+ | RORγt | ||||
NKT10 | PD-1, ICOS, Nrp1 | E4BP4 |
