Fig. 1: Schematic representation of generation of hACE2 expressing transgenic pigs.
From: Human ACE2 transgenic pigs are susceptible to SARS-CoV-2 and develop COVID-19-like disease
A custom lentiviral vector with the human K18 promoter driving hACE2 expression was microinjected into the perivitelline space of putative zygotes. Zygotes were then implanted into surrogate gilts (Created in BioRender. Grey, F. (2023) https://BioRender.com/l58r269).
