Fig. 1: Manhattan plot showing results of PheWAS between 36,085 TRs and 30,291 traits in 168,554 individuals from the UKB. | Nature Communications

Fig. 1: Manhattan plot showing results of PheWAS between 36,085 TRs and 30,291 traits in 168,554 individuals from the UKB.

From: A phenome-wide association study of tandem repeat variation in 168,554 individuals from the UK Biobank

Fig. 1: Manhattan plot showing results of PheWAS between 36,085 TRs and 30,291 traits in 168,554 individuals from the UKB.

Associations that exceed a Bonferroni-corrected significance threshold of p < 1.45 × 10−10 (horizontal dashed line) are shown as colored points. High-confidence fine-mapped variants, corresponding to those identified by two independent methods, are shown as red-filled points, while all other significant associations are shown as open orange circles. Note the discontinuous y-axis and modified scale used to show results with −log10 p > 100, which was used to display strong association signals observed at several loci. Full results are shown in Supplementary Data 3 and 4. P values were calculated using linear and logistic regression implemented in REGENIE, applying a Bonferroni correction based on 9531 independent traits and 36,085 TRs analyzed.

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