Fig. 1: Cellular landscape of the minor salivary glands of SjS patients.
From: Molecular and spatial analysis of tertiary lymphoid structures in Sjogren’s syndrome
a Minor salivary gland (mSG) biopsy 10x single cell workflow pipeline, Created in BioRender. NAYAR, S. (2024) https://BioRender.com/l06g537. b Uniform manifold approximation and projection (UMAP) embedding of 17,011 single cells and gross-cell identities clustering of single-cell gene expression data from n = 7 Sjogren’s syndrome (SjS) salivary gland samples illustrating both immune and stromal cell clusters. c Multiplex immunofluorescence image illustrating major lineages identified in minor salivary gland tissue from Sjogren’s patients (n = 3) probed with a 6-plex panels for CD146 (green), VE-cadherin or CD20 (yellow), Pan-Cytokeratin/CK (magenta), CD138 (orange), and CD68 + CD11c (cyan), CD45 or CD8 (white), Podoplanin/PDPN+CD90 or CD3 (red) and CD4 (blue), Scale bar = 50 µm.
