Fig. 8: ASCL1 and OLIG2 shared target cell type-specific genes are differentially expressed in control and Ascl1-OE tumors. | Nature Communications

Fig. 8: ASCL1 and OLIG2 shared target cell type-specific genes are differentially expressed in control and Ascl1-OE tumors.

From: Transcription factors ASCL1 and OLIG2 drive glioblastoma initiation and co-regulate tumor cell types and migration

Fig. 8: ASCL1 and OLIG2 shared target cell type-specific genes are differentially expressed in control and Ascl1-OE tumors.

a–c ChIP-seq tracks demonstrating shared binding of ASCL1 and OLIG2 at cis-regulatory sites of OPC/oligodendroglial (a), NSC/astroglial (b), and microglial lineage genes (c) and UMAP showing differential expression in control and Ascl1-OE cell clusters. All genes illustrated are shared targets of ASCL1 and OLIG2.

Back to article page