Fig. 7: Ig gene repertoires in neonatal and adult SHIV infection. | Nature Communications

Fig. 7: Ig gene repertoires in neonatal and adult SHIV infection.

From: Neonatal immunity associated with heterologous HIV-1 neutralizing antibody induction in SHIV-infected Rhesus Macaques

Fig. 7

At month 12 post-infection, we interrogated the Ig gene usages and their immunogenetics that contribute to the B cell receptor (BCR) repertoires in neonate (V055 and V093) and adult (BG15 and V060) SHIV-infected RMs. Neonate and dam pairs: V055/BG15 and V093/V060. Shown are the frequencies of VH gene families VH1-VH7 (A), HCDR3 length distribution as percentages (B) and SHM frequencies of VH genes of different antibody isotypes (IgA, IgD, IgG and IgM) (C), used by BCRs of neonate and adult SHIV-infected RMs. Frequencies were shown as a portion of 1 and percentages shown as a portion of 100. Macaque Ig genes were computationally inferred using macaque reference databases. For panel (C), the box is the interquartile range of 25th percentile to the 75th percentile of the data with the median also shown, and the whiskers show the upper and lower bounds of the mutation frequencies. A–C Source data are provided as a Source Data file.

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