Fig. 3: Cryo-EM structure of the 7TM-bound ADGRL3 HormR/GAIN domains at 3.9 Å resolution. | Nature Communications

Fig. 3: Cryo-EM structure of the 7TM-bound ADGRL3 HormR/GAIN domains at 3.9 Å resolution.

From: Conformational coupling between extracellular and transmembrane domains modulates holo-adhesion GPCR function

Fig. 3

a The cryo-EM structure and density map of HormR/GAIN domains of ADGRL3 bound to sAB LK3. HormR domain is colored purple, GAIN - green, TA - magenta, and heavy and light chains of LK3 - yellow. b Close-up view of the intact TA buried within the GAIN domain in the holoreceptor. Side chains of the TA peptide are shown as sticks. c and d Glycosylation of conserved sites N843 (c) and N814 (d) at the membrane-facing side of the GAIN domain modeled into the density map of HormR/GAIN domains.

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