Fig. 7: Proposed model for TrxA binding and toxicity of TreX.
From: Thioredoxin 1 moonlights as a chaperone for an interbacterial ADP-ribosyltransferase toxin
a Structural comparison of the TrxA (purple) binding to its substrate PAPS (left, PDB code: 2O8V), its client T7 polymerase (middle, PDB code: 6P7E), and TreX toxin (right). TrxA is shown in purple, PAPS in pink, T7 polymerase in cyan, DNA in gray, TreX in red, and TriX in green. b Model of secretion of TreX (red), activation by TrxA (purple), and growth inhibition by ADP-ribosylation of FtsZ (blue).
