Table 3 Associations between skeletal muscle oxidative capacity and white matter microstructural measures of mean diffusivity and fractional anisotropy via DTI (n = 639)

From: Higher skeletal muscle mitochondrial oxidative capacity is associated with preserved brain structure up to over a decade

		Fractional Anisotropy (higher value: higher integrity)
		Cross-sectional associations			Longitudinal associations
		β	SE	p-value	β	SE	p-value
Commissural fibers	Genu of corpus callosum	0.0480	0.0329	0.1448	0.0010	0.0044	0.8118
	Body of corpus callosum	0.0298	0.0361	0.4092	0.0072	0.0036	0.0458
	Splenium of corpus callosum	0.0816	0.0401	0.0426	0.0068	0.0037	0.0648
Association fibers	External capsule	0.0080	0.0309	0.7956	0.0023	0.0051	0.6496
	Uncinate fasciculus	−0.0297	0.0411	0.4706	−0.0022	0.0049	0.6575
	Superior longitudinal fasciculus	−0.0159	0.0382	0.6780	0.0077	0.0038	0.0442
	Inferior longitudinal fasciculus	0.0002	0.0393	0.9955	0.0024	0.0042	0.5577
	Superior fronto-occipital fasciculus	0.0208	0.0385	0.5891	0.0056	0.0052	0.2861
	Inferior fronto-occipital fasciculus	0.0057	0.0390	0.8829	0.0071	0.0054	0.1903
	Cingulate part of the cingulum	0.0319	0.0390	0.4143	0.0067	0.0036	0.0644
	Hippocampal part of the cingulum	0.0135	0.0381	0.7231	0.0108	0.0059	0.0648
	Fornix (column and body)	0.0413	0.0338	0.2223	0.0025	0.0029	0.3955
	Fornix (cres) Stria terminalis	0.0549	0.0328	0.0943	0.0076	0.0040	0.0578
Projection fibers	Anterior limb of the internal capsule	0.0070	0.0348	0.8403	0.0037	0.0050	0.4596
	Posterior limb of the internal capsule	−0.0185	0.0398	0.6428	0.0063	0.0061	0.3071
	Anterior corona radiata	−0.0096	0.0321	0.7642	−0.0010	0.0031	0.7402
	Superior corona radiata	−0.0337	0.0397	0.3962	0.0000	0.0036	0.9954
	Posterior corona radiata	−0.0445	0.0409	0.2778	0.0024	0.0039	0.5429
Cerebellum	Cerebellar peduncle	0.0481	0.0361	0.1833	0.0017	0.0080	0.8327
		Mean Diffusivity (lower value: higher integrity)
		Cross-sectional associations			Longitudinal associations
		β	SE	p-value	β	SE	p-value
Commissural fibers	Genu of corpus callosum	−0.0563	0.0334	0.0921	−0.0021	0.0046	0.6508
	Body of corpus callosum	−0.0401	0.0335	0.2315	−0.0052	0.0040	0.1921
	Splenium of corpus callosum	−0.0842	0.0385	0.0292	−0.0052	0.0038	0.1714
Association fibers	External capsule	−0.0032	0.0292	0.9117	−0.0014	0.0036	0.6946
	Uncinate fasciculus	0.0016	0.0356	0.9649	0.0057	0.0046	0.2077
	Superior longitudinal fasciculus	0.0083	0.0337	0.8053	−0.0040	0.0044	0.3552
	Inferior longitudinal fasciculus	−0.0190	0.0375	0.6136	−0.0044	0.0059	0.4553
	Superior fronto-occipital fasciculus	−0.0121	0.0335	0.7173	−0.0002	0.0049	0.9591
	Inferior fronto-occipital fasciculus	−0.0150	0.0323	0.6419	−0.0052	0.0040	0.1997
	Cingulate part of the cingulum	−0.0653	0.0356	0.0670	−0.0042	0.0054	0.4363
	Hippocampal part of the cingulum	−0.0837	0.0390	0.0325	−0.0068	0.0059	0.2522
	Fornix (column and body)	−0.0423	0.0332	0.2038	0.0014	0.0027	0.5944
	Fornix (cres) Stria terminalis	−0.0523	0.0339	0.1228	−0.0012	0.0038	0.7596
Projection fibers	Anterior limb of the internal capsule	−0.0204	0.0328	0.5340	−0.0002	0.0046	0.9678
	Posterior limb of the internal capsule	−0.0249	0.0336	0.4584	−0.0105	0.0054	0.0522
	Anterior corona radiata	0.0035	0.0334	0.9170	0.0002	0.0039	0.9493
	Superior corona radiata	−0.0121	0.0332	0.7146	−0.0020	0.0040	0.6185
	Posterior corona radiata	0.0000	0.0378	0.9998	−0.0034	0.0038	0.3669
Cerebellum	Cerebellar peduncle	−0.0493	0.0369	0.1819	−0.0017	0.0071	0.8095

Note: Statistical results are from linear mixed effects models with significance at two-sided p < 0.05. Bold number indicates p < 0.05. k_PCr and diffusion tensor imaging (DTI) values are standardized to Z scores.

Back to article page

Table 3 Associations between skeletal muscle oxidative capacity and white matter microstructural measures of mean diffusivity and fractional anisotropy via DTI (n = 639)

Search

Quick links