Fig. 2: PICNIC has the best performance in predicting condensate-forming proteins. | Nature Communications

Fig. 2: PICNIC has the best performance in predicting condensate-forming proteins.

From: PICNIC accurately predicts condensate-forming proteins regardless of their structural disorder across organisms

Fig. 2

Comparison of sequence-based predictors (PICNIC, PdPS-8fea, PSAP, and DeePhase) of condensate proteins using different metrics. a Test dataset from PhaSepDB high-throughput retrieved from29 (441 positive and 1998 negative examples, excluding proteins that were part of the PICNIC training set), (b) test dataset from OpenCell42 (78 positive and 1998 negative examples excluding proteins that were part of the PICNIC training set), (c) test dataset from the current study based on CD-CODE34 (338 positive and 299 negative examples, i.e proteins that were not part of the PICNIC training set). PICNIC outperforms sequence-based predictors even on the test set that includes training data of previously published predictors, that may inflate their performance. Source data are provided as a Source Data file.

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