Fig. 7: Inferring condensate proteins across the tree of life reveals no correlation with disorder content. | Nature Communications

Fig. 7: Inferring condensate proteins across the tree of life reveals no correlation with disorder content.

From: PICNIC accurately predicts condensate-forming proteins regardless of their structural disorder across organisms

Fig. 7

a PICNIC model is species-independent. We validated the PICNIC model on known condensate proteins from 14 different species (defined by CD-CODE)34. PICNIC correctly identified 70–100% of known condensate proteins of all species tested, except for zebrafish (50%). b Proteome-wide prediction of proteins in biomolecular condensates by PICNIC predictor. c Disorder content and fraction of condensate-forming proteins of a proteome are not correlated. The fraction of disordered proteins (proteins with at least one disordered region of > = 40 residues) in proteomes shows no correlation across 26 selected organisms from bacteria, archaea to mammals (Pearson R2 = 0.08). Source data are provided as a Source Data file.

Back to article page