Fig. 7: H3K56ac collaborates with the chromatin remodelers Isw1 and Chd1 in chromatin maturation.
From: H3K56 acetylation regulates chromatin maturation following DNA replication
Schematic working model. a In WT cells, symmetrical distribution of H3K56ac leads to an equal distribution of closely-packed nucleosomes and/or subnucleosomal particles (not depicted here) in nascent chromatin originated from both leading and lagging strand synthesis. b In mcm2-3A cells, the enrichment of H3K56ac in nascent chromatin from the lagging strand enhances the chromatin remodeling activity of Isw1 and Chd1, resulting in an extension of the nucleosome repeat length. On the other hand, a reduced levels of H3K56ac at leading strands leads to an increased levels of closely-packed nucleosomes. Created in BioRender. Zhou, H. (2024) https://BioRender.com/k19f998.
