Fig. 5: Simulations highlight changes in economic wiring constraints across development.
From: Premature birth changes wiring constraints in neonatal structural brain networks
a Energy significantly decreased across PMA (p < 2.00 × 10-16) and GA at birth (p = 7.00 × 10-3). The relationship between energy and GA at birth was linear. b η significantly decreased across PMA (p < 2.00 × 10−16) but increased across GA at birth (p = 8.61 x 10-6). γ significantly increased across PMA (p < 2.00 × 10-16) but decreased across GA at birth (p = 0.018). Model parameters predicted by PMA become more constrained (higher γ, lower η) as age increases. Model parameters predicted by GA at birth indicate that preterm infants have higher γ, but lower η compared to term infants. Yellow points indicate mean parameters for preterm (circle) and term (triangle) groups. All results presented are generalized additive models. Shaded area around best fit lines represent 95% confidence intervals. The grey dotted line indicates the cut-off for term birth (37 weeks GA or later is term-born). *** indicates p < 0.001, ** indicates p < 0.01, * indicates p < 0.05.
