Fig. 6: Two-component reactions of N-tosylhydrazones with 3-nitroindole 3a or N-tosylimine 5a. | Nature Communications

Fig. 6: Two-component reactions of N-tosylhydrazones with 3-nitroindole 3a or N-tosylimine 5a.

From: Three-component diels-alder reaction through palladium carbene migratory insertion enabled dearomative C(sp3)-H bond activation

Fig. 6: Two-component reactions of N-tosylhydrazones with 3-nitroindole 3a or N-tosylimine 5a.The alternative text for this image may have been generated using AI.

a Reaction of 2a with 3-nitroindole 3a or imine 5a in presence of base. b Reaction of 9a with 3-nitroindole 3a or imine 5a in presence of base. Reaction condition A: K2CO3 (3.0 equiv), toluene (0.1 M), 80 °C, Ar, 12 h. Reaction condition B: i K3PO4 (4.0 equiv), toluene (0.1 M), 80 °C, Ar, 12 h; ii DDQ (1.2 equiv), ethyl acetate (0.2 M), RT, 6 h. Me: methyl, Ts: 4-methylbenzenesulfonyl, Boc: t-butyloxycarbonyl, DDQ: 2,3-dichloro-5,6-dicyanobenzoquinone, RT: room temperature.

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