Fig. 7: Proposed schematic model of ISC Myc regulation.
From: STAT1 regulates immune-mediated intestinal stem cell proliferation and epithelial regeneration
While regulation of ISC Myc expression may be primarily Wnt-driven at baseline, we propose that there is additional STAT1-dependent regulation of Myc expression driven by IFNγ in the setting of GVHD.
