Fig. 2: Micro-C reveals interactions among RNAPII transcription start sites.
From: Inter-chromosomal transcription hubs shape the 3D genome architecture of African trypanosomes
a IC-normalized and ploidy-corrected heat maps of Hi-C (bottom left) and Micro-C (top right) of megabase chromosomes 1-11 (haplotype A) at 50 kb resolution (left) with each chromosome displayed with the core region in white, subtelomeric regions in light gray and centromeres displayed as black lines; part of chromosome 10 of the same heat maps is displayed at 5 kb resolution (right), with polycistronic transcription units of chromosome 10 illustrated as black arrows (top). b Aggregate analysis of Micro-C data around pairs of intra-chromosomal TSSs (n = 2342 TSS-TSS pairs); control loci are obtained from the same pairs of loci shifted downstream by 20 kb. c Aggregate analysis of Micro-C data around pairs of inter-chromosomal TSSs (n = 20,008 TSS-TSS pairs); control loci are obtained from the same pairs of loci shifted downstream by 20 kb. d Aggregate peak analysis of Hi-C and Micro-C data around chromatin loops (i.e., pairs of bins with high interaction frequency) identified in the Micro-C matrix using Mustache (with a p-value threshold of 0.02 and a sparsity threshold of 0.85; n = 367).
