Fig. 5: Kaplan Meier curve of progression-free survival.

Based on (A) Time to progression based on depth of response of VGPR of greater. p = 8.0e-4 VGPR = Very good partial response (B) PFS by depth of response of VGPR of greater amongst cytogenetically high-risk patients (high-risk cytogenetics identified by FISH alone). C PFS by depth of response of VGPR of greater amongst cytogenetically high-risk patients (High-risk patients identified by FISH, WGS, or single-cell RNA sequencing.) p = 3.1e-4. D Kaplan-Meier curve of progression-free-survival stratified by patients who achieved sustained CR with progression defined by SLiM-CRAB criteria. CR complete response. E Kaplan-Meier curve of duration of response stratified by patients who achieved sustained CR. F Kaplan-Meier curve of Biochemical progression-free-survival stratified by sustained CR status. G Kaplan Meier curve of progression-free survival based on MRD status. NR not reached. Survival distributions were compared using two-sided log-rank tests. Source data are provided as a Source Data file.