Fig. 3: An antidepressant exposure methylation profile score (MPS) and antidepressant exposure in external cohorts.
From: Insights from a methylome-wide association study of antidepressant exposure
A The number of participants exposed and unexposed to antidepressants in each cohort (NNTR = 3087, NSTRADL = 658, NFTC = 1678, NSHIP-TREND = 495, NALSPAC = 801, NLBC1936 = 889, NMARS-UniDep = 312, NERISK = 1658, NFOR2107 = 658). B Nagelkerke’s pseudo R2, representing an estimate of how much variance in the antidepressant exposure outcome that is explained by the MPS in each cohort. C The effect estimates and 95% confidence intervals (effect estimate +/− 1.96*Standard Error) of MPS ~ antidepressant exposure association in each cohort, using either a generalised linear model (FOR2107 and ALSPAC), a generalised linear mixed model (SHIP-Trend, LBC1936, MARS-UniDep, STRADL and E-Risk) or a generalised estimation equation model (FTC and NTR). The square size = study weight in the random-effects meta-analysis. The pooled effect estimate interval, calculated from a random-effects meta-analysis, is represented by the blue diamond (Npooled=10,236). Created in BioRender. Davyson, E. (2024) https://BioRender.com/q70l792.
