Table 1 Demographics and structured clinical interview of the DSM (SCID) diagnoses of antidepressant exposed and unexposed individuals using the prescription-derived and self-reported antidepressant exposure phenotypes in Generation Scotland
From: Insights from a methylome-wide association study of antidepressant exposure
Prescription-derived phenotype | Self-report phenotype | |||
|---|---|---|---|---|
Unexposed | Exposed | Unexposed | Exposed | |
N | 7090 | 861 | 15028 | 1508 |
Age: M (SD) | 47.6 (15.2) | 51.1 (12.7) | 46.6 (14.9) | 50.2 (12.4) |
BMI: M (SD) | 26.4 (4.78) | 28.5 (6.11) | 26.4 (5.01) | 28.2 (6.05) |
Sex | ||||
Female: N (%) | 3747 (53) | 631 (73) | 8556 (57) | 1154 (77) |
Male: N (%) | 3343 (47) | 230 (27) | 6467(43) | 354 (23) |
Smoking behaviours | ||||
Current: N (%) | 963 (14) | 214 (25) | 2448 (16) | 402 (27) |
Former: N (%) | 1942 (27) | 273 (32) | 4183 (28) | 481 (32) |
Never: N (%) | 3913 (55) | 328 (38) | 8114 (54) | 576 (38) |
Pack years: M (SD) | 6.3 (13.1) | 12 (17.1) | 6.55 (13.3) | 11.6 (16.9) |
Structured Clinical Interview for DSM IV (SCID) | ||||
No Major Disorder: N (%) | 6514 (92) | 373 (43) | 12704 (85) | 556 (37) |
Bipolar Disorder | 9 (0.1) | 9 (1) | 29 (0.2) | 23 (1.5) |
Single Episode MDD N (%) | 281 (4) | 137 (16) | 880 (6) | 260 (17) |
Recurrent MDD: N (%) | 131 (2) | 243 (28) | 622 (4) | 506 (34) |
MDD cases (Recurrent & Single Episode): N (%) | 412 (6) | 380 (44) | 1502 (10) | 766 (51) |
