Table 2 Eight CpGs associated with self-reported (SR) and/or prescription-derived (PD) antidepressant use
From: Insights from a methylome-wide association study of antidepressant exposure
Probe | Significant in SR / PD MWAS | Chr | BP | Gene | \(\beta\)SR | SESR | PSR | \(\beta\)PD | SEPD | PPD | Other traits associated with the CpG (EWAS catalog)79 |
|---|---|---|---|---|---|---|---|---|---|---|---|
cg26277237 | SR + PD | 9 | 631910 | KANK1 | 0.024 | 0.0033 | 9.3 × 10−13 | 0.027 | 0.0044 | 6.1 × 10−10 | C-reactive protein levels80 (basic model), Chronic kidney disease (basic model)81, Type 2 diabetes (basic model)81, Estimated glomerular filtration rate82 |
cg04173586 | SR + PD | 19 | 2167496 | DOT1L | 0.023 | 0.0036 | 2.35 × 10−10 | 0.034 | 0.0048 | 7 × 10−13 | Alcohol consumption83, COVID-19 severity (basic model)81, Sex84, Age85, Alzheimer’s disease Braak stage86, Estimated glomerular filtration rate82, Schizophrenia87 |
cg08907118 | SR only | 16 | 27482516 | GTF3C1 | 0.021 | 0.0039 | 6.46 × 10−8 | 0.027 | 0.0052 | 3.0 × 10−7 | C-reactive protein levels (basic model)80, Chronic pain (basic model)81, Type 2 diabetes (basic model)81, Sex84, Age85 |
cg02183564 | SR only | 7 | 76874892 | CCDC146 | 0.019 | 0.0028 | 3.59 × 10−11 | 0.019 | 0.0037 | 5.17 × 10−7 | Birthweight85, C-reactive protein levels (basic model)80, Gestational age88, Chronic pain (basic model)81, Type 2 diabetes (basic model)81, Age85 |
cg15071067 | SR-only | 2 | 74196550 | DGUOK-AS1 | 0.018 | 0.0032 | 9.84 × 10−9 | 0.020 | 0.0042 | 3.3 × 10−6 | C-reactive protein levels (basic model)80, Incident chronic pain (basic model)81, Incident type 2 diabetes (basic & fully adjusted model)81, Chronic pain (self-report)81, Type 2 diabetes (basic model)81 |
cg01964004 | PD only | 2 | 74196572 | DGUOK-AS1 | 0.017 | 0.0036 | 1.3 × 10−6 | 0.026 | 0.0047 | 3.0 × 10−8 | C-reactive protein levels (basic model)80, Incident type 2 diabetes (basic & fully adjusted model)81, Chronic pain (basic model)81, Ischemic heart disease (basic model)81, Type 2 diabetes (basic model)81 |
cg03222540 | SR only | 15 | 90575080 | ZNF710 | 0.014 | 0.002 | 2.05 × 10−8 | 0.014 | 0.0034 | 3.7 × 10−7 | C-reactive protein levels (basic model)80, Chronic kidney disease (basic model)81, Type 2 diabetes (basic & fully adjusted model)81 |
cg04315689 | SR + PD | 2 | 74198896 | DGUOK-AS1 | 0.014 | 0.0026 | 5.56 × 10−8 | 0.019 | 0.0035 | 3.85 × 10−8 | C-reactive protein levels (basic model)80, Incident type 2 diabetes (basic model)81, Chronic kidney disease (basic & fully adjusted model)81, Chronic pain (basic model)81, Type 2 diabetes (basic & fully adjusted model)81 |
