Fig. 1: Cellular landscape of human endometrium across the window of implantation. | Nature Communications

Fig. 1: Cellular landscape of human endometrium across the window of implantation.

From: Time-series single-cell transcriptomic profiling of luteal-phase endometrium uncovers dynamic characteristics and its dysregulation in recurrent implantation failures

Fig. 1: Cellular landscape of human endometrium across the window of implantation.

a Schematic summary of the experimental design. Endometrial cells from fertile control and RIF were processed by single-cell 3’ transcriptomic sequencing. Created in BioRender. Gong (2024) https://BioRender.com/c12o660. b UMAP plots of a total of 220,248 cells and epithelial, stromal, NK/T, and myeloid subsets color-coded by major cell types (left) and subpopulations (right), respectively. c The expression of marker genes for the major cell types. d The RNA velocity trajectory (left) and latent time (right) for epithelial cell subpopulations. e Immunostaining of luminal marker genes (CDH1, LGR5, EDG7) and glandular marker gene (FOXA2) in endometrium of proliferative phase (n = 3). G: gland. f Immunostaining of epithelial cell marker EPCAM and stromal cell marker VIM in LH + 5 endometrial tissue (n = 1). Results for other time points could be found in Supplementary Fig. 5 (n = 4 in total). Source data are provided as a Source Data file.

Back to article page