Fig. 1: CryoEM reconstruction and modeling of the G115 (Vγ9 Vδ2) TCR/CD3 complex.
From: Structural characterization of two γδ TCR/CD3 complexes
a Left and middle: two views of a 3.27 Å resolution map of the G115 TCR/CD3 complex bound by OKT3 fab. Right: cryoEM map was Gaussian filtered to 2.5 σ and the contour level was reduced to allow visualization of a weak γδ TCR ECD density. b Structure of the G115 TCR/CD3 complex. Interfaces between TCRγ/TCRδ (c), TCRγ/CD3εγ (d), TCRγ/CD3ζ (e), TCRδ/CD3εδ (f), and TCRδ/CD3ζζ (g). Chains are shown in cartoon representation and color-coded as indicated and interfacial residues are shown as sticks. Underlined residues highlight conserved electrostatic interactions between αβ and γδ TCR-CD3 interaction networks.
