Fig. 5: Agonistic antibody binding modes in the absence and presence of Gi proteins.
From: Structural insights into the regulation of monomeric and dimeric apelin receptor
a Structural model of the dimeric JN241-9-APJR complex. APJR is depicted in purple; JN241-9 is shown in light pink surface. b Structural model of the monomeric JN241-9-APJR-Gi complex. APJR is illustrated in green; JN241-9 is represented in blue surface; Gαi, Gβ, and Gγ are colored in light cyan, light green, and light blue, respectively. c Interactions between the Y105 residue in JN241-9 and APJR in the absence of Gi proteins. The interacting residues are shown as sticks. Structural comparison of JN241-9 within the JN241-9-APJR and JN241-9-APJR-Gi complexes shown in side view (d) and top view (e). The conformational rotation of Y105 during G protein coupling is indicated with arrows. f Interactions between the Y105 residue in JN241-9 and APJR in the presence of Gi proteins. The interacting residues are shown as sticks.
