Fig. 6: Norathyriol inverts circPETH-147aa-facilitated intrahepatic metastasis of HCC cells and enhances tumor-killing effects of CD8+ T cells. | Nature Communications

Fig. 6: Norathyriol inverts circPETH-147aa-facilitated intrahepatic metastasis of HCC cells and enhances tumor-killing effects of CD8+ T cells.

From: The protein circPETH-147aa regulates metabolic reprogramming in hepatocellular carcinoma cells to remodel immunosuppressive microenvironment

Fig. 6: Norathyriol inverts circPETH-147aa-facilitated intrahepatic metastasis of HCC cells and enhances tumor-killing effects of CD8+ T cells.

a, b Top: Representative bioluminescence photographs of liver orthotopic implanted intrahepatic metastasis models with indicated Hep3B and Huh-7 cells. Norathyriol was intraperitoneally injected (5 mg/kg or 10 mg/kg, once daily for 2 weeks). Middle: Representative fluorescence and brightfield photographs of intrahepatic metastatic nodules in liver orthotopic implanted intrahepatic metastasis models with indicated Hep3B and Huh-7 cells. Bottom: Representative HE staining of metastatic foci in the liver. Scale bars from top to bottom: 1.2 cm, 7.5 mm, 7.5 mm, 2.8 mm, 280 μm, 70 μm. n = 5 for each group. c Flow cytometry analysis of indicated Hep3B and Huh-7 cells cocultured with CD8+ T cells and treated with Norathyriol at different concentrations for 24 h. Data are representative of at least three independent experiments. Source data are provided as a Source Data file.

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