Table 1 Structure-activity-relationship study of coumarin derivatives for in vitro binding affinities with SL5 RNA

From: Chemical-guided SHAPE sequencing (cgSHAPE-seq) informs the binding site of RNA-degrading chimeras targeting SARS-CoV-2 5’ untranslated region

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Name

R1

R2

R3

SL5 Kd (µM)

C2

CH2CH3

-

-

1.45 ± 0.38

C4

H

-

-

1.24 ± 0.29

C6

CH2CH2NHBoc

-

-

5.67 ± 4.78

C29

-

H

H

0.47 ± 0.09

C30

-

H

F

0.22 ± 0.09

C31

-

F

H

0.69 ± 0.07

C32

-

H

Cl

0.42 ± 0.09

C36

-

H

CF3

1.41 ± 0.25

C34

-

H

OMe

0.14 ± 0.03

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