Table 1 Patient baseline demographics and clinical characteristics

From: Sitravatinib in combination with nivolumab plus ipilimumab in patients with advanced clear cell renal cell carcinoma: a phase 1 trial

Age, years

Median (IQR)

58 (51–62)

Range

36–76

Sex, n (%)

Male

17 (77.3)

Female

5 (22.7)

Ethnicity, n (%)

White

17 (77.3)

Black

2 (9.1)

East Asian

2 (9.1)

South Asian

1 (4.5)

IMDC prognostic risk group, n (%)

Favorable

1 (4.5)

Intermediate

19 (86.4)

Poor

2 (9.1)

Baseline peripheral blood NLR

Median (IQR)

2.38 (1.85–3.74)

Range

1.07–7.29

Karnofsky performance status score, n (%)

100

14 (63.6)

90

1 (4.5)

80

5 (22.7)

70

2 (9.1)

Previous nephrectomy, n (%)

Yes

15 (88.2)

No

7 (11.8)

Previous radiotherapy, n (%)

Yes

2 (9.1)

No

20 (90.9)

Target lesions per RECIST 1.1, n (%)

1

6 (27.3)

≥ 2

16 (72.7)

Most common active sites of metastasis, n (%)

Lung

19 (86.4)

Lymph node

14 (63.6)

Bone

4 (18.2)

Liver

2 (9.1)

Sarcomatoid/rhabdoid histology, n (%)

Yes

6 (27.3)

No

16 (72.7)

  1. IMDC International Metastatic RCC Database Consortium, IQR interquartile range, NLR neutrophil-to-lymphocyte ratio, RECIST Response Evaluation Criteria in Solid Tumors