Fig. 1: G4 DNA sequences in PKD1. | Nature Communications

Fig. 1: G4 DNA sequences in PKD1.

From: G-quadruplex stabilization provokes DNA breaks in human PKD1, revealing a second hit mechanism for ADPKD

Fig. 1

a A basic G4 DNA sequence motif and model of a G4 structure. Guanines (G) pair with one another to form stacks of tetrads. Created in BioRender. Bouma, J. (2024) BioRender.com/n41z770. b G4 motifs quantitated for human (H), mouse (M) and rat (R) PKD1 with QGRS mapper22, using a 45 nt. window, 3G minimum, and 8 nt. loop. c G4 motifs (+) mapped onto the sense strand of human, mouse, and rat PKD1. hPKD1 intron 1, 21, and 34 are marked (red text).

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