Fig. 4: The MRP2 transport cycle. | Nature Communications

Fig. 4: The MRP2 transport cycle.

From: Structural basis for the transport and regulation mechanism of the multidrug resistance-associated protein 2

Fig. 4

A In the absence of substrate, MRP2 rests in an auto-inhibited state. Colored as in Fig. 1B. Dotted magenta lines represent unresolved regions of R domain. In this state, ATP-binding does not induce NBD dimerization, but rather stabilizes R domain in the auto-inhibiting position. B Substrate displaces R domain from the auto-inhibited conformation. C Substrate is released in the NBD-dimerized conformation.

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