Fig. 2: Cortical gray matter volume trajectories based on the functional location of the changes in gestational mothers (N = 179).
The different trajectories were assessed by parcellating the brain in Yeo’s seven large-scale functional brain networks14. A Cortical parcellation of Yeo’s seven large-scale functional brain networks. B Mean percentage of cortical GM volume change per group and session and functional location in relation to the baseline (i.e., Session 1 - Pre-pregnancy Session). The gray shading corresponds to the pregnancy period. C Vertex-wise signed effect size maps (ηp2) of the group x session2 interaction (q value < 0.05 and ηp2 > 0.06 to capture medium to big effect sizes). Indicating larger quadratic effects (red) and smaller quadratic effects (blue) in gestational mothers than in nulliparous. Signed effect size maps were projected to the inflated fsaverage template provided by the FreeSurfer software. Colors were collapsed to ±0.14, which indicated a large effect size. Gest, gestational mothers; Null, nulliparous women. D Spin test for the signed effect sizes of the vertex-wise Group [gestational mothers vs nulliparous women]*Session2 interaction in cortical volume within the seven large-scale functional brain networks. Black horizontal bars represent the observed values and the violin plots reflect the null distributions obtained using 1000 spin-permutations of the maps. The exact one-tailed p values are reported when p < 0.05. No multiple comparisons corrections were applied. The black dot on the center of the boxplot represents the median, the box encloses the lower and upper quartiles, and the whiskers extend to the minimum and maximum values within a range of 1.5 times the interquartile range.
