Fig. 1: Overview of BA.2.86 lineage specific spike protein mutations relative to BA.2. | Nature Communications

Fig. 1: Overview of BA.2.86 lineage specific spike protein mutations relative to BA.2.

From: Reverse mutational scanning of SARS-CoV-2 spike BA.2.86 identifies epitopes contributing to immune escape from polyclonal sera

Fig. 1: Overview of BA.2.86 lineage specific spike protein mutations relative to BA.2.

A Schematic representation of the SARS-CoV-2 spike domains and amino acid changes indicated for BA.2.86, and shared by XBB.1.5, and EG.5.1 compared to the spike of BA.2. Further mutations within XBB.1.5 and EG.5.1 relative to BA.2 are not shown, as only sites mutated within BA.2.86 are represented. N-terminal domain (NTD, blue), receptor binding domain (RBD, green), Subdomains 1 and 2 (SD1 and SD2, orange), S2 subunit (orange). Created in BioRender. Bdeir, N. (2024) BioRender.com/m05k539 and in the references add: Bdeir, N. (2024). Figure A. Created in BioRender. BioRender.com/m05k539. B Model of the trimeric spike protein of BA.2.86, calculated with AlphaFold2/AlphaFold-Multimer27,45. The N-terminal secretion signal (15 residues) and the C-terminal membrane-anchoring sequence (112 residues) were omitted from calculations, leading to 3372 residues in the final model. Domains have been colored according to panel A, and one of five independently calculated models is shown. Spheres represent the location of mutations with respect to the spike protein of BA.2. The positions of deletions are colored in green, red spheres indicate mutations that lead to enhanced immune escape of BA.2.86, other mutations are shown in blue. For clarity, mutations are only shown in one chain of the spike trimer. C Magnified view of one trimer extracted from the model shown in B and shown in the same orientation.

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