Table 1 Detectable neutralization titer frequencies and geometric mean (GM) titers of the six nAb markers (D614G, Delta, Beta, BA.1, BA.4/BA.5, weighted average) in SARS-CoV-2 naïve participants, shown separately by non-cases and COVID-19 endpoint cases (stratified by booster-proximal cases and booster-distal cases)

From: Neutralizing antibody immune correlates in COVAIL trial recipients of an mRNA second COVID-19 vaccine boost

  

Booster-Proximal COVID-19 Cases

Booster-Distal COVID-19 Cases

Non-cases

Comparison: Non-cases to Booster-Proximal COVID-19 Cases

Comparison: Non-cases to Booster-Distal COVID-19 Cases

Visit

nAb Titer Marker

N

Pos Resp Freq (95% CI)

GM (95% CI)

N

Pos Resp Freq (95% CI)

GM (95% CI)

N

Pos Resp Freq (95% CI)

GM (95% CI)

Pos Resp Freq Diff (Non-cases – Cases) (95% CI)

Ratio of GM (Non-cases/Cases) (95% CI)

Pos Resp Freq Diff (Non-cases – Cases) (95% CI)

Ratio of GM (Non-cases/Cases) (95% CI)

D1

D614G

122

99.2% (95.5%, 100.0%)

2509 (1998, 3151)

59

100.0% (93.9%, 100.0%)

2368 (1909, 2938)

448

98.4% (96.8%, 99.4%)

2775 (2446, 3148)

−0.7% (-2.6%, 3.0%)

1.11 (0.85, 1.45)

−1.6% (−3.2%, 4.6%)

1.17 (0.82, 1.67)

D1

Delta

122

96. 7% (91.8%, 99.1%)

1127 (883, 1439)

59

100.0% (93.9%, 100.0%)

1067 (857, 1326)

448

97.1% (95.1%, 98.4%)

1311 (1149, 1496)

0.4% (−2.7%, 5.5%)

1.16 (0.88, 1.54)

−2.9% (−4.9%, 3.3%)

1.23 (0.85, 1.78)

D1

Beta

122

93.4% (87.5%, 97.1%)

567 (439, 733)

59

91.5% (81.3%, 97.2%)

413 (293, 581)

448

92.0% (89.0%, 94.3%)

647 (558, 751)

−1.5% (−6.2%, 4.9%)

1.14 (0.83, 1.56)

0.4% (−5.9%, 10.9%)

1.57 (1.03, 2.40)

D1

BA.1

122

68.9% (59.8%, 76.9%)

155 (115, 207)

59

71.2% (57.9%, 82.2%)

134 (93.3, 191)

448

75.9% (71.7%, 79.8%)

203 (174, 236)

7.0% (−2.1%, 16.9%)

1.31 (0.95, 1.82)

4.7% (−7.1%, 18.5%)

1.52 (0.98, 2.35)

D1

BA.4/5

122

50.8% (41.6%, 60.0%)

80.4 (61.5, 105)

59

45.8% (32.7%, 59.2%)

65.7 (45.8, 94.0)

448

59.4% (54.7%, 64.0%)

110 (95.1, 128)

8.6% (−1.7%, 18.8%)

1.37 (1.00, 1.88)

13.6% (−0.7%, 27.4%)

1.68 (1.10, 2.58)

D1

Wt Avg

122

-

331 (260, 422)

59

-

280 (211, 370)

448

-

410 (359, 469)

-

1.24 (0.93, 1.65)

-

1.47 (1.00, 2.15)

D15

D614G

122

100.0% (97.0%, 100.0%)

17,833 (15,271, 20,826)

59

100.0% (93.9%, 100.0%)

13,638 (11,246, 16,539)

448

99.8% (98.8%, 100.0%)

18,485 (16,797, 20,342)

−0.2% (−1.2%, 2.8%)

1.04 (0.85, 1.27)

−0.2% (−1.2%, 5.8%)

1.36 (1.03, 1.78)

D15

Delta

122

100.0% (97.0%, 100.0%)

9557 (8146, 11,213)

59

100.0% (93.9%, 100.0%)

7684 (6311, 9356)

448

99.8% (98.8%, 100.0%)

10,090 (9131, 11,150)

−0.2% (−1.2%, 2.8%)

1.06 (0.86, 1.30)

−0.2% (−1.2%, 5.8%)

1.31 (0.99, 1.74)

D15

Beta

122

100.0% (97.0%, 100.0%)

7462 (6215, 8959)

59

100.0% (93.9%, 100.0%)

5932 (4586, 7672)

448

99.6% (98.4%, 99.9%)

8208 (7305, 9223)

−0.4% (−1.6%, 2.6%)

1.10 (0.86, 1.40)

−0.4% (−1.6%, 5.6%)

1.38 (0.99, 1.93)

D15

BA.1

122

100.0% (97.0%, 100.0%)

3006 (2482, 3641)

59

100.0% (93.9%, 100.0%)

2685 (2096, 3440)

448

98.2% (96.5%, 99.2%)

3240 (2844, 3690)

−1.8% (−3.5%, 1.4%)

1.08 (0.82, 1.41)

−1.8% (−3.5%, 4.4%)

1.21 (0.83, 1.74)

D15

BA.4/5

122

98.4% (94.2%, 99.8%)

1150 (923, 1433)

59

98.3% (90.9%, 100.0%)

963 (736, 1260)

448

95.8% (93.5%, 97.4%)

1315 (1156, 1496)

−2.6% (−5.3%, 1.9%)

1.14 (0.87, 1.50)

−2.5% (−5.4%, 5.0%)

1.37 (0.95, 1.97)

D15

Wt Avg

122

-

4247 (3576, 5043)

59

-

3513 (2808, 4395)

448

-

4628 (4149, 5162)

-

1.09 (0.87, 1.37)

-

1.32 (0.97, 1.80)

  1. Wt Avg = Maximum diversity-weighted geometric mean of the five nAb titers D614G reference, Beta, Delta, Omicron BA.1, and Omicron BA.4/BA.5.
  2. Non-cases: No evidence of SARS-CoV-2 infection at 7 days post-D15 through to 188 days post-D15.
  3. Booster-proximal cases: COVID-19 endpoint between 7 and 91 days post-D15 visit; booster-distal cases: COVID-19 endpoint between 92 and 188 days post-D15 visit.
  4. Pos Resp Freq: Percent with nAb titer above the limit of detection (LoD) = 40 AU/ml. Diff = Difference.
  5. AU arbitrary units, GMT geometric mean titer.
Back to article page