Table 2 Detectable neutralization titer frequencies and geometric mean (GM) titers of the six nAb markers (D614G, Delta, Beta, BA.1, BA.4/BA.5, weighted average) in SARS-CoV-2 non-naïve participants, shown separately by non-cases and COVID-19 endpoint cases (stratified by booster-proximal cases and booster-distal cases)

From: Neutralizing antibody immune correlates in COVAIL trial recipients of an mRNA second COVID-19 vaccine boost

  

Booster-Proximal COVID-19 Cases

Booster-Distal COVID-19 Cases

Non-cases

Comparison: Non-cases to Booster-Proximal COVID-19 Cases

Comparison: Non-cases to Booster-Distal COVID-19 Cases

Visit

nAb Titer Marker

N

Pos Resp Freq (95% CI)

GM (95% CI)

N

Pos Resp Freq (95% CI)

GM (95% CI)

N

Pos Resp Freq (95% CI)

GM (95% CI)

Pos Resp Freq Diff (Non-cases – Cases) (95% CI)

Ratio of GM (Non-cases/Cases) (95% CI)

Pos Resp Freq Diff (Non-cases – Cases) (95% CI)

Ratio of GM (Non-cases/Cases) (95% CI)

D1

D614G

22

95.5% (77.2%, 99.9%)

4935 (2310, 10,539)

10

100.0% (69.2%, 100.0%)

8428 (5666, 12,536)

324

99.1% (97.3%, 99.8%)

11,944 (10,513, 13,571)

3.6% (−1.1%, 21.9%)

2.42 (1.44, 4.08)

−0.9% (−2.7%, 29.9%)

1.42 (0.68, 2.93)

D1

Delta

22

90.9% (70.8%, 98.9%)

1926 (872, 4257)

10

100.0% (69.2%, 100.0%)

4945 (3329, 7346)

324

99.1% (97.3%, 99.8%)

6040 (5324, 6853)

8.2% (0.0%, 28.2%)

3.14 (1.86, 5.27)

−0.9% (−2.7%, 29.9%)

1.22 (0.60, 2.51)

D1

Beta

22

95.5% (77.2%, 99.9%)

1925 (920, 4025)

10

100.0% (69.2%, 100.0%)

3262 (1847, 5761)

324

99.1% (97.3%, 99.8%)

4643 (4034, 5344)

3.6% (−1.1%, 21.9%)

2.41 (1.37, 4.25)

−0.9% (−2.7%, 29.9%)

1.42 (0.64, 3.18)

D1

BA.1

22

90.9% (70.8%, 98.9%)

544 (277, 1070)

10

100.0% (69.2%, 100.0%)

1465 (686, 3132)

324

97.8% (95.6%, 99.1%)

1848 (1593, 2145)

6.9% (−1.3%, 27%)

3.40 (1.88, 6.14)

−2.2% (−4.4%, 28.7%)

1.26 (0.54, 2.96)

D1

BA.4/5

22

81.8% (59.7%, 94.8%)

309 (155, 617)

10

100.0% (69.2%, 100.0%)

849 (561, 1283)

324

97.5% (95.2%, 98.9%)

1158 (1012, 1324)

15.7% (2.5%, 37.9%)

3.75 (2.18, 6.44)

−2.5% (−4.8%, 28.4%)

1.36 (0.63, 2.94)

D1

Wt Avg

22

-

985 (514, 1889)

10

-

2265 (1393, 3682)

324

-

3033 (2665, 3452)

-

3.08 (1.83, 5.18)

-

1.34 (0.64, 2.80)

D15

D614G

22

100.0% (84.6%, 100.0%)

18,578 (13,116, 26,315)

10

100.0% (69.2%, 100.0%)

37,681 (21,529, 65,949)

324

99.7% (98.3%, 100.0%)

37,075 (33,597, 40,912)

−0.3% (−1.7%, 15.1%)

2.00 (1.36, 2.94)

−0.3% (−1.7%, 30.5%)

0.98 (0.56, 1.73)

D15

Delta

22

100.0% (84.6%, 100.0%)

10,827 (7266, 16,132)

10

100.0% (69.2%, 100.0%)

18,938 (9654, 37,149)

324

99.7% (98.3%, 100.0%)

21,669 (19,574, 23,987)

−0.3% (−1.7%, 15.1%)

2.00 (1.34, 2.99)

−0.3% (−1.7%, 30.5%)

1.14 (0.64, 2.05)

D15

Beta

22

100.0% (84.6%, 100.0%)

10,765 (6887, 16,828)

10

100.0% (69.2%, 100.0%)

22,257 (10,306, 48,065)

324

99.7% (98.3%, 100.0%)

22,483 (20,059, 25,200)

−0.3% (−1.7%, 15.1%)

2.09 (1.33, 3.27)

−0.3% (−1.7%, 30.5%)

1.01 (0.52, 1.95)

D15

BA.1

22

100.0% (84.6%, 100.0%)

4060 (2863, 5759)

10

100.0% (69.2%, 100.0%)

11,520 (4833, 27,460)

324

99.1% (97.3%, 99.8%)

10,257 (8995, 11,697)

−0.9% (−2.7%, 14.5%)

2.53 (1.52, 4.21)

−0.9% (−2.7%, 29.9%)

0.89 (0.42, 1.90)

D15

BA.4/5

22

100.0% (84.6%, 100.0%)

1822 (1168, 2842)

10

100.0% (69.2%, 100.0%)

4210 (2136, 8299)

324

98.8% (96.9%, 99.7%)

4934 (4336, 5615)

−1.2% (−3.1%, 14.2%)

2.71 (1.63, 4.49)

−1.2% (−3.1%, 29.6%)

1.17 (0.56, 2.46)

D15

Wt Avg

22

-

5697 (3961, 8193)

10

-

12,819 (6396, 25,693)

324

-

13,207 (11,841, 14,731)

-

2.32 (1.51, 3.55)

-

1.03 (0.55, 1.93)

  1. Wt Avg = Maximum diversity-weighted geometric mean of the five nAb titers D614G reference, Beta, Delta, Omicron BA.1, and Omicron BA.4/BA.5.
  2. Non-cases: No evidence of SARS-CoV-2 infection at 7 days post-D15 through to 188 days post-D15.
  3. Booster-proximal cases: COVID-19 endpoint between 7 and 91 days post-D15 visit; booster-distal cases: COVID-19 endpoint between 92 and 188 days post-D15 visit.
  4. Pos Resp Freq: Percent with nAb titer above the limit of detection (LoD) = 40 AU/ml. Diff = Difference.
  5. AU arbitrary units, GMT geometric mean titer.
Back to article page