Fig. 6: RDEB adults nurse a particular eicosanoids signature.
From: Systems immunology integrates the complex endotypes of recessive dystrophic epidermolysis bullosa
a Schematic representation of lipid mediators downstream polyunsaturated fatty acid (PUFA). b Heatmap representing mean values of serum eicosanoid lipid mediators’ relative abundance from healthy controls (n = 8) and RDEB adults (n = 12). Colours vary according to lipid abundance density. c–e Relative abundance of altered eicosanoids derived from acid arachidonic (AA) downstream cyclooxygenase (COX), lipoxygenase (LOX/FLAP), and cytochrome P450 (CYP450) pathways, linoleic acid (LA), and docosahexaenoic acid (DHA). Lipid mediators are presented in scattered plots as mean values of relative abundance/ml of sera ± SEM from 8 healthy controls and 12 RDEB adults. Healthy controls (black triangles) and RDEB adults (red circles). Statistical analysis is performed with two-sided unpaired t-test. Asterisks represent the significant differences between healthy controls and RDEB adults (*p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001). Source data are provided as a Source Data file.
