Fig. 1: SOAT2 involved in immune infiltration predicts poor prognosis in elderly patients with lung squamous carcinoma.

A Kaplan-Meier survival curves of LSCC patients grouped by age (The Old ≥ 65-year-old, n = 293; The Young <65-year-old, n = 166) in TCGA-LSCC cohort. B, C The infiltration of immune (B) and stromal (C) cells in the old and young populations. D, E Kaplan–Meier curves depicted Overall Survival in the old and young populations with high infiltration of immune (The Old: n = 149, The Young: n = 80) (D) and stromal (The Old: n = 151, The Young: n = 78) (E) cells. F, G Kaplan–Meier curves depicted Overall Survival in the old and young populations with low infiltration of immune (The Old: n = 144, The Young: n = 86) (D) and stromal (The Old: n = 142, The Young: n = 88) cells. H Venn diagram for screening differentially expressed genes in elderly patients based on tumor microenvironment immune and stromal cell infiltration differences. I Cox proportional hazards regression analysis showed 6 differentially expressed genes were related to elderly LSCC patient’s prognosis (n = 459). J The gene set enrichment analysis indicated SOAT2 related signaling network. K, L The relative mRNA expression of SOAT2 was interrogated in the blood (K, Age 20–29: n = 29, 30–39: n = 19, 40–49: n = 48, 50–59: n = 81, 60–69: n = 78) and spleens (L, Age 20–29: n = 9, 30–39: n = 12, 40–49: n = 26, 50–59: n = 34, 60–69: n = 16) with different age in GTEx data. M The mRNA expression of SOAT2 was interrogated in the old and young populations by GSE62627 database (The Young: n = 13, The Old: n = 13). Data represented means ± SD. Statistical difference was evaluated by unpaired two-tailed student’s t-test (B, C, M), and one-way ANOVA test (K, L). Source data are provided as a Source Data file. (*P value < 0.05; **P < 0.01; ns no significance).